GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6044112 | 1 | rs6075069 | chr20:16528914 | KIF16B | chr20:16252749-16554078:- | -0.26 | -4.87 | 1.5E-6 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs607541 | 1 | rs607541 | chr15:45934869 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.93 | 1.15E-6 | Obesity-related traits |
| THCA | cis | rs11671653 | 1 | rs60755785 | chr19:10839494 | SLC44A2 | chr19:10713121-10755234:+ | 0.3 | 3.4 | 0.000743 | LDL cholesterol |
| THCA | cis | rs607541 | 1 | rs607594 | chr15:45934840 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.93 | 1.15E-6 | Obesity-related traits |
| THCA | cis | rs7267979 | 1 | rs6076336 | chr20:25319212 | ENTPD6 | chr20:25176339-25207360:+ | 0.31 | 6.94 | 1.24E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076336 | chr20:25319212 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.4 | 0.000741 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076336 | chr20:25319212 | FAM182B | chr20:25744102-25848786:- | -0.27 | -5.62 | 3.21E-8 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076336 | chr20:25319212 | NINL | chr20:25433338-25566153:- | 0.35 | 7.18 | 2.68E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076336 | chr20:25319212 | PYGB | chr20:25228706-25278647:+ | 0.16 | 4.05 | 5.93E-5 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076339 | chr20:25348712 | ENTPD6 | chr20:25176339-25207360:+ | 0.31 | 7.01 | 8.16E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076339 | chr20:25348712 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.43 | 0.000655 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076339 | chr20:25348712 | FAM182B | chr20:25744102-25848786:- | -0.26 | -5.45 | 7.92E-8 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076339 | chr20:25348712 | NINL | chr20:25433338-25566153:- | 0.33 | 6.9 | 1.62E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076339 | chr20:25348712 | PYGB | chr20:25228706-25278647:+ | 0.16 | 3.98 | 8.02E-5 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076345 | chr20:25381895 | ENTPD6 | chr20:25176339-25207360:+ | 0.32 | 7.24 | 1.85E-12 | Liver enzyme levels (alkaline phosphatase) |